Titel: Frontotemporal demens heterogen sjukdomsgrupp [summary] (serie: Tema demens) 2009 nr 20 sid 1381-5

Läs/ladda hem artikeln: Översikt Fullständig referenslista Artikeln i pdf-format (utskriftskvalitet) Artikeln i webbversion Sid 1381 Sid 1382 Sid 1383 Sid 1384 Sid 1385 Om Läkartidningens fulltext på Internet Hämta Acrobat Reader

Ämnesord:
Demens
Hjärna
Terminologi, principer



















Sök liknande artiklar (ny funktion på försök)

Summary:
Frontotemporal lobar degeneration (FTLD) or frontotemporal dementia (FTD) is a clinically and neuropathologically heterogeneous group of primary degenerative dementia diseases. The clinical representation consists of progressive psychiatric and/or neurological symtoms such as behavioural changes, language or motor dysfunction. FTD is usually divided into the following subgroups: Behavioural variant FTD (FTD-bv), semantic dementia (SD), progressive non-fluent aphasia (PNFA) and FTD with motor neuron disease (FTD-MND). Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) show both clinical and neuropathological similarities to FTD, and therefore are often considered being part of the FTD complex. Knowledge about the great diversity in phenotype of FTD facilitates early refererral and diagnosis of patients, which is necessary for adequate support and treatment.

Maria Landqvist, Christina Elfgren, Elisabet Englund, Christer Nilsson, Ulla Passant

Correspondence: Maria Landqvist, Avdelningen för geriatrisk psykiatri, Verksamhetsområde Kognitiv medicin, Universitetssjukhuset, SE-221 85 Lund, Sweden
maria.landqvist@med.lu.se

Referenser:
1.Onari K, Spatz H. Anatomische Beiträge zur Lehre von der Pickschen umschriebenen Grosshirnrinden-Atrophie ('Picksche Krankheit'). Z Neurol 1926;101:470-511.
2.Brun A. Frontal lobe degeneration of non-Alzheimer type. I. Neuropathology. Arch Gerontol Geriatr 1987;6(3):193-208.
3.Gustafson L. Frontal lobe degeneration of non-Alzheimer type. II. Clinical picture and differential diagnosis. Arch Gerontol Geriatr 1987;6(3):209-23.
4.Brun A, Gustafson L. The Lund Longitudinal Dementia Study: A 25-year perspective on neuropathology, differential diagnosis and treatment. In: Corain B, Iqbal K, Nicolini M, Winblad B, Wisniewski H, Zatta P, editors. Alzheimer's disease: Advances in clinical and basic research: John Wiley and Sons, Ldt; 1993. p. 4-18.
5.Brunnstrom H, Gustafson L, Passant U, Englund E. Prevalence of dementia subtypes: A 30-year retrospective survey of neuropathological reports. Arch Gerontol Geriatr 2008.
6.Ratnavalli E, Brayne C, Dawson K, Hodges JR. The prevalence of frontotemporal dementia. Neurology 2002;58(11):1615-21.
7.Neary D, Snowden J, Mann D. Frontotemporal dementia. Lancet Neurol 2005;4(11):771-80.
8.Stevens M, van Duijn CM, Kamphorst W, de Knijff P, Heutink P, van Gool WA, et al. Familial aggregation in frontotemporal dementia. Neurology 1998;50(6):1541-5.
9.Rosso SM, Donker Kaat L, Baks T, Joosse M, de Koning I, Pijnenburg Y, et al. Frontotemporal dementia in The Netherlands: patient characteristics and prevalence estimates from a population-based study. Brain 2003;126(Pt 9):2016-22.
10.Kumar-Singh S, Van Broeckhoven C. Frontotemporal lobar degeneration: current concepts in the light of recent advances. Brain Pathol 2007;17(1):104-14.
11.Brun A, Englund E, Gustafson L, Passant U, Mann DMA, Neary D, et al. Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups. J Neurol Neurosurg Psychiatry 1994;57(4):416-8.
12.Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S, et al. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 1998;51(6):1546-54.
13.Kertesz A, Munoz D. Relationship between frontotemporal dementia and corticobasal degeneration/progressive supranuclear palsy. Dement Geriatr Cogn Disord 2004;17(4):282-6.
14.Josephs KA, Petersen RC, Knopman DS, Boeve BF, Whitwell JL, Duffy JR, et al. Clinicopathologic analysis of frontotemporal and corticobasal degenerations and PSP. Neurology 2006;66(1):41-8.
15.Kertesz A, McMonagle P, Blair M, Davidson W, Munoz DG. The evolution and pathology of frontotemporal dementia. Brain 2005;128(Pt 9):1996-2005.
16.Passant U, Elfgren C, Englund E, Gustafson L. Psychiatric symptoms and their psychosocial consequences in frontotemporal dementia. Alzheimer Dis Assoc Disord 2005;19 Suppl 1:S15-8.
17.Grasbeck A, Englund E, Horstmann V, Passant U, Gustafson L. Predictors of mortality in frontotemporal dementia: a retrospective study of the prognostic influence of pre-diagnostic features. Int J Geriatr Psychiatry 2003;18(7):594-601.
18.Mesulam MM. Primary progressive aphasia: a 25-year retrospective. Alzheimer Dis Assoc Disord 2007;21(4):S8-S11.
19.Blair M, Marczinski CA, Davis-Faroque N, Kertesz A. A longitudinal study of language decline in Alzheimer's disease and frontotemporal dementia. J Int Neuropsychol Soc 2007;13(2):237-45.
20.Shinagawa S, Ikeda K, Fukuhara R, Tanabe H. Initial symptoms in frontotemporal dementia and semantic dementia compared with Alzheimer's disease. Dement Geriatr Cogn Disord 2006;21:74-80.
21.Strong MJ. The syndromes of frontotemporal dysfunction in amyothrophic lateral sclerosis. Amyotrophic Lateral Sclerosis 2008:1-16.
22.Hodges JR, Davies R, Xuereb J, Kril J, Halliday G. Survival in frontotemporal dementia. Neurology 2003;61(3):349-54.
23.Lomen-Hoerth C. Characterization of amyotrophic lateral sclerosis and frontotemporal dementia. Dement Geriatr Cogn Disord 2004;17(4):337-41.
24.Josephs KA, Rossor MN. The alien limb. Practical Neurology 2004;4:44-45.
25.Nath U, Ben-Shlomo Y, Thomson RG, Lees AJ, Burn DJ. Clinical features and natural history of progressive supranuclear palsy: a clinical cohort study. Neurology 2003;60(6):910-6.
26.Kaat LD, Boon AJ, Kamphorst W, Ravid R, Duivenvoorden HJ, van Swieten JC. Frontal presentation in progressive supranuclear palsy. Neurology 2007;69(8):723-9.
27.Hodges JR, Patterson K, Oxbury S, Funnell E. Semantic dementia. Progressive fluent aphasia with temporal lobe atrophy. Brain 1992;115:1783-1806.
28.Nestor PJ, Graham NL, Fryer TD, Williams GB, Patterson K, Hodges JR. Progressive non-fluent aphasia is associated with hypometabolism centred on the left anterior insula. Brain 2003;126(Pt 11):2406-18.
29.Andreasen N, Blennow K. CSF biomarkers for mild cognitive impairment and early Alzheimer's disease. Clin Neurol Neurosurg 2005;107(3):165-73.
30.Englund E, Brun A. Frontal lobe degeneration of non-Alzheimer type. IV. White matter changes. Arch Gerontol Geriatr 1987;6(3):235-43.
31.Larsson E, Passant U, Sundgren PC, Englund E, Brun A, Lindgren A, et al. Magnetic resonance imaging and histopathology in dementia, clinically of frontotemporal type. Dement Geriatr Cogn Disord 2000;11(3):123-34.
32.Brun A, Gustafson L. Limbic lobe involvement in presenile dementia. Arch Psychiatr Nervenkr 1978;226(2):79-93.
33.Dickson DW, Bergeron C, Chin SS, Duyckaerts C, Horoupian D, Ikeda K, et al. Office of Rare Diseases neuropathologic criteria for corticobasal degeneration. J Neuropathol Exp Neurol 2002;61(11):935-46.
34.Hodges JR, Davies RR, Xuereb JH, Casey B, Broe M, Bak TH, et al. Clinicopathological correlates in frontotemporal dementia. Ann Neurol 2004;56(3):399-406.
35.Graham A, Davies R, Xuereb J, Halliday G, Kril J, Creasey H, et al. Pathologically proven frontotemporal dementia presenting with severe amnesia. Brain 2005;128(Pt 3):597-605.
36.Freedman M. Frontotemporal dementia: recommendations for therapeutic studies, designs, and approaches. Can J Neurol Sci 2007;34 Suppl 1:S118-24.
37.Swartz JR, Miller BL, Lesser IM, Darby AL. Frontotemporal dementia: treatment response to serotonin selective reuptake inhibitors. J Clin Psychiatry 1997;58(5):212-6.
38.Deakin JB, Rahman S, Nestor PJ, Hodges JR, Sahakian BJ. Paroxetine does not improve symptoms and impairs cognition in frontotemporal dementia: a double-blind randomized controlled trial. Psychopharmacology (Berl) 2004;172(4):400-8.
39.Swedish Movement Disorder Society. Svenska riktlinjer för utredning och behandling av Parkinsons sjukdom. Maj, 2007.
40.Passant U, Gustafson L. Patienter med frontallobsdemens. Nationellt kunskapscentrum arbetar mot brister i omhändertagandet. Läkartidningen 2001;98:3682-3684.