 | 
|
| |
|
Titel: Benvävnadens omsättning [summary] (serie: Tema osteoporos) 2006 nr 40 sid 2972-5
|
Summary:
The skeleton is not static, but is continuously remodelled throughout life by the processes of bone resorption and bone formation. Old bone is first removed (resorbed) by highly specialized multinucleated cells of hematopoetic origin which are termed osteoclasts. Following resorption by osteoclasts, mesenchymally derived cells termed osteoblasts are recruited to the sites of eroded bone (lacunae) where they lay down new bone. In a healthy skeleton, the resorption and formation processes are balanced, resulting in the preservation of bone mass. In post-menopausal osteoporosis, the lack of estrogen causes increased bone turnover to occur. This altered remodelling is characterized by greater bone resorption than formation, leading to decreased bone mass. Drugs used today for the treatment of post-menopausal osteoporosis are mainly anti-resorptive agents such as bisphosphonates, estrogen and selective estrogen receptor modulators (SERMs). Recently, stimulation of bone formation by intermittent treatment with parathyroid hormone has also been employed as a treatment.
Ulf H. Lerner, Östen Ljunggren
Correspondence:
Ulf H. Lerner, Avdelningen för oral cellbiologi, Medicinska fakulteten, Umeå Universitet, 901 87 Umeå, ulf.lerner@odont.umu.se
 2972 |
 2973 |
 2974 |
 2975 |