Titel: Progressiv afasi. Nya rön om bortglömt fenomen [summary] 2002 nr 17 sid 1941-4

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Ämnesord:
Afasi, primär progressiv
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Summary:
Progressive aphasia
New data on an old phenomenon
Per Östberg, Christian Andersen, Lars-Olof Wahlund
Läkartidningen 2002;99:1941-4
Progressive aphasias are distinct but infrequently recognized clinical expressions of non-Alzheimer lobar atrophy. We review and illustrate two such syndromes - semantic dementia (SD) and progressive nonfluent aphasia (PA). SD involves loss of conceptual structure due to bilateral infratemporal atrophy. PA is a phonetic-syntactic disorder resulting from left perisylvian atrophy. Early research on Pick disease - originally defined as circumscribed cerebrocortical atrophy - highlighted left temporal lobe atrophy and aphasia. For this reason (among others), Pick disease or Pick complex is still a useful and convenient label for progressive aphasias and other clinical manifestations of non-AD lobar atrophy.
Correspondence: Lars-Olof Wahlund, Huddinge Universitetssjukhus, B84, SE-141 86 Stockholm, Sweden
(lars-olof.wahlund@neurotec.ki.se)